ABSTRACT
Background: Neurodegenerative diseases are those affect the central nervous system (brain, spinal cord) and peripheral nervous system. It is characterized by progressive loss of neurons and synapses in these nervous systems. Calcium homeostasis receives key attention in the past few years in the field of neuronal physiology of Ageing and Neurodegenerative diseases. Objective: The aim of this study was to evaluate Calcium homeostasis in patients with Neurodegenerative diseases. Methods: 50 subjects (36 males and 14females) with Neurodegenerative diseases. And same number of healthy age-matched subject control group was assessed. A complete & detailed neurological examination were performed in all individuals and clinically evaluated for the occurrence of Neurodegenerative diseases. Calcium levels were estimated using (Instrumentation Laboratory – IlyteTM) Automated Electrolyte Analyzer, with solution pack and reagents. Results: ‘The Serum Calcium (Ca2+) levels were estimated and comparison was done in both control and case group separately, for evaluating the changes due to ageing and in particular to neurodegenerative diseases. Conclusion: Neurodegenerative diseases showed significant differences in Calcium homeostasis.
ABSTRACT
Background: Parkinson’s disease (PD) is a progressive long-term, neurodegenerative disorder of central nervous system which mainly affects the motor system, caused by loss of dopaminergic neurons in the substantia nigra, but also in other dopaminergic and non-dopaminergic areas of the brain and mainly in the brainstem. Brainstem Auditory Evoked Response are routinely used in clinical practice to evaluate the function of the auditory nerve and auditory pathways in the brainstem. Objective: The aim of this study was to evaluate the Brainstem Auditory Evoked Response in patients with Parkinson’s disease. Methods30 subjects (18 males and 12females) with Parkinson’s disease. And same number of healthy age-matched subject control group was assessed. Age of Control Group was 61.2±11.6 & of Test Group 61.7±10.4. A complete & detailed neurological examination (CNS) were performed in all individuals clinically especially of motor system to evaluate the severity of the disease for the occurrence of Parkinson’s disease. Recordings of BAERs were performed with Neurostim Plus software of Medicaid Company, using 70 dB HL in the form of rarefaction clicks were used in each ear obtain good quality BAER recording. Results. The BAER results were interpreted for the latencies and Interpeak latencies. The result of this study shows that the waves II, III, IV, V and IPL III-V were significantly delayed. Conclusion. Parkinson’s disease population showed significant differences to Brainstem Auditory Evoked Response